mir-160 microRNA precursor family

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mir-160 microRNA precursor family
Symbol mir-160
Rfam RF00247
miRBase MI0000190
miRBase family MIPF0000032
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO 0035195 0035068
SO 0001244
PDB structures PDBe

In molecular biology, mir-160 is a microRNA that has been predicted or experimentally confirmed in a range of plant species including Arabidopsis thaliana (mouse-ear cress) and Oryza sativa (rice).[1] miR-160 is predicted to bind complementary sites in the untranslated regions of auxin response factor genes to regulate their expression.[2] The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 5' arm of the hairpin.

Specifically, 3 of A. thaliana's 23 auxin-response factor genes are thought to be post-transcriptionally regulated by mir-160.[3][4] When one of these targets (ARF17) is manipulated to become miRNA-resistant, several developmental defects can be observed in the host plant.[3] This experiment has been repeated with another mir-160 target, ARF10, and results highlighted a regulatory role in post-embryonic development and seed germination.[5]


  1. ^ "miRNA gene family: MIR160". mirBASE. University of Manchester. Archived from the original on 15 July 2012. Retrieved 5 September 2011. 
  2. ^ Rhoades, MW; Reinhart BJ; Lim LP; Burge CB; Bartel B; Bartel DP (2002). "Prediction of plant microRNA targets". Cell. 110 (4): 513–520. doi:10.1016/S0092-8674(02)00863-2. PMID 12202040. 
  3. ^ a b Mallory, AC; Bartel, DP; Bartel, B (May 2005). "MicroRNA-directed regulation of Arabidopsis AUXIN RESPONSE FACTOR17 is essential for proper development and modulates expression of early auxin response genes". The Plant Cell. 17 (5): 1360–75. doi:10.1105/tpc.105.031716. PMC 1091760Freely accessible. PMID 15829600. 
  4. ^ Liu, X; Huang, J; Wang, Y; Khanna, K; Xie, Z; Owen, HA; Zhao, D (May 2010). "The role of floral organs in carpels, an Arabidopsis loss-of-function mutation in MicroRNA160a, in organogenesis and the mechanism regulating its expression". The Plant journal : for cell and molecular biology. 62 (3): 416–28. doi:10.1111/j.1365-313X.2010.04164.x. PMID 20136729. 
  5. ^ Liu, PP; Montgomery, TA; Fahlgren, N; Kasschau, KD; Nonogaki, H; Carrington, JC (October 2007). "Repression of AUXIN RESPONSE FACTOR10 by microRNA160 is critical for seed germination and post-germination stages". The Plant journal : for cell and molecular biology. 52 (1): 133–46. doi:10.1111/j.1365-313X.2007.03218.x. PMID 17672844. 

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