mir-196 microRNA precursor family

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mir-196 microRNA precursor family
Symbol mir-196
Rfam RF00256
miRBase MI0000238
miRBase family MIPF0000031
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO 0035195 0035068
SO 0001244
PDB structures PDBe

miR-196 is a non-coding RNA called a microRNA that has been shown to be expressed in human (MI0000238[permanent dead link], MI0000279) and mouse (MI0000552, MI0000553).[1][2] miR-196 appears to be a vertebrate specific microRNA and has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000031[permanent dead link]). In many species the miRNA appears to be expressed from intergenic regions in HOX gene clusters. The hairpin precursors are predicted based on base pairing and cross-species conservation—their extents are not known. In this case the mature sequence is excised from the 5' arm of the hairpin.

It has been suggested that a rare SNP (rs11614913) that overlaps has-mir-196a2 has been found to be associated with non-small cell lung carcinoma.[3]

Further reading[edit]

[4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24]


  1. ^ Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (2003). "New microRNAs from mouse and human". RNA. 9 (2): 175–9. doi:10.1261/rna.2146903. PMC 1370382Freely accessible. PMID 12554859. 
  2. ^ Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (2003). "Vertebrate microRNA genes". Science. 299 (5612): 1540. doi:10.1126/science.1080372. PMID 12624257. 
  3. ^ Hu Z, Chen J, Tian T, Zhou X, Gu H, Xu L, Zeng Y, Miao R, Jin G, Ma H, Chen Y, Shen H (2008). "Genetic variants of miRNA sequences and non-small cell lung cancer survival". J Clin Invest. 118 (7): 2600–8. doi:10.1172/JCI34934. PMC 2402113Freely accessible. PMID 18521189. 
  4. ^ Zhang XW, Pan SD, Feng YL, Liu JB, Dong J, Zhang YX, Chen JG, Hu ZB, Shen HB (2011). "[Relationship between genetic polymorphism in microRNAs precursor and genetic prediposition of hepatocellular carcinoma]". Zhonghua Yu Fang Yi Xue Za Zhi. 45 (3): 239–43. PMID 21624236. 
  5. ^ Georges M (2011). "The long and winding road from correlation to causation". Nat Genet. 43 (3): 180–1. doi:10.1038/ng0311-180. PMID 21350497. 
  6. ^ Brest P, Lapaquette P, Souidi M, Lebrigand K, Cesaro A, Vouret-Craviari V, Mari B, Barbry P, Mosnier JF, Hébuterne X, Harel-Bellan A, Mograbi B, Darfeuille-Michaud A, Hofman P (2011). "A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease". Nat Genet. 43 (3): 242–5. doi:10.1038/ng.762. PMID 21278745. 
  7. ^ Chen C, Zhang Y, Zhang L, Weakley SM, Yao Q (2011). "MicroRNA-196: critical roles and clinical applications in development and cancer". J Cell Mol Med. 15 (1): 14–23. doi:10.1111/j.1582-4934.2010.01219.x. PMC 3276076Freely accessible. PMID 21091634. 
  8. ^ Scagnolari C, Zingariello P, Vecchiet J, Selvaggi C, Racciatti D, Taliani G, Riva E, Pizzigallo E, Antonelli G (2010). "Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha". Virol J. 7: 311. doi:10.1186/1743-422X-7-311. PMC 2996368Freely accessible. PMID 21070682. 
  9. ^ Li Y, Zhang M, Chen H, Dong Z, Ganapathy V, Thangaraju M, Huang S (2010). "Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis". Cancer Res. 70 (20): 7894–904. doi:10.1158/0008-5472.CAN-10-1675. PMC 2955846Freely accessible. PMID 20736365. 
  10. ^ Guan Y, Mizoguchi M, Yoshimoto K, Hata N, Shono T, Suzuki SO, Araki Y, Kuga D, Nakamizo A, Amano T, Ma X, Hayashi K, Sasaki T (2010). "MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance". Clin Cancer Res. 16 (16): 4289–97. doi:10.1158/1078-0432.CCR-10-0207. PMID 20601442. 
  11. ^ Asli NS, Kessel M (2010). "Spatiotemporally restricted regulation of generic motor neuron programs by miR-196-mediated repression of Hoxb8". Dev Biol. 344 (2): 857–68. doi:10.1016/j.ydbio.2010.06.003. PMID 20553899. 
  12. ^ Schotte D, Lange-Turenhout EA, Stumpel DJ, Stam RW, Buijs-Gladdines JG, Meijerink JP, Pieters R, Den Boer ML (2010). "Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia". Haematologica. 95 (10): 1675–82. doi:10.3324/haematol.2010.023481. PMC 2948092Freely accessible. PMID 20494936. 
  13. ^ Hou W, Tian Q, Zheng J, Bonkovsky HL (2010). "MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins". Hepatology. 51 (5): 1494–504. doi:10.1002/hep.23401. PMC 2862129Freely accessible. PMID 20127796. 
  14. ^ McGlinn E, Yekta S, Mansfield JH, Soutschek J, Bartel DP, Tabin CJ (2009). "In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation". Proc Natl Acad Sci U S A. 106 (44): 18610–5. doi:10.1073/pnas.0910374106. PMC 2773993Freely accessible. PMID 19846767. 
  15. ^ Sehm T, Sachse C, Frenzel C, Echeverri K (2009). "miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events". Dev Biol. 334 (2): 468–80. doi:10.1016/j.ydbio.2009.08.008. PMID 19682983. 
  16. ^ Popovic R, Riesbeck LE, Velu CS, Chaubey A, Zhang J, Achille NJ, Erfurth FE, Eaton K, Lu J, Grimes HL, Chen J, Rowley JD, Zeleznik-Le NJ (2009). "Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization". Blood. 113 (14): 3314–22. doi:10.1182/blood-2008-04-154310. PMC 2665896Freely accessible. PMID 19188669. 
  17. ^ Sonkoly E, Ståhle M, Pivarcsi A (2008). "MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation". Semin Cancer Biol. 18 (2): 131–40. doi:10.1016/j.semcancer.2008.01.005. PMID 18291670. 
  18. ^ Woltering JM, Durston AJ (2008). "MiR-10 represses HoxB1a and HoxB3a in zebrafish". PLoS ONE. 3 (1): e1396. doi:10.1371/journal.pone.0001396. PMC 2148072Freely accessible. PMID 18167555. 
  19. ^ Richardson MK, Crooijmans RP, Groenen MA (2007). "Sequencing and genomic annotation of the chicken (Gallus gallus) Hox clusters, and mapping of evolutionarily conserved regions". Cytogenet Genome Res. 117 (1-4): 110–9. doi:10.1159/000103171. PMID 17675851. 
  20. ^ Kawasaki H, Taira K (2004). "MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells". Nucleic Acids Symp Ser (Oxf) (48): 211–2. doi:10.1093/nass/48.1.211. PMID 17150553. 
  21. ^ Chopra VS, Mishra RK (2006). ""Mir"acles in hox gene regulation". BioEssays. 28 (5): 445–8. doi:10.1002/bies.20401. PMID 16615131. 
  22. ^ Ronshaugen M, Biemar F, Piel J, Levine M, Lai EC (2005). "The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings". Genes Dev. 19 (24): 2947–52. doi:10.1101/gad.1372505. PMC 1315399Freely accessible. PMID 16357215. 
  23. ^ Hornstein E, Mansfield JH, Yekta S, Hu JK, Harfe BD, McManus MT, Baskerville S, Bartel DP, Tabin CJ (2005). "The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development". Nature. 438 (7068): 671–4. doi:10.1038/nature04138. PMID 16319892. 
  24. ^ Yekta S, Shih IH, Bartel DP (2004). "MicroRNA-directed cleavage of HOXB8 mRNA". Science. 304 (5670): 594–6. doi:10.1126/science.1097434. PMID 15105502. 

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