mir-451 microRNA

From Wikipedia, the free encyclopedia
Jump to: navigation, search
mir-451
MiR-451 secondary structure.png
miR-451 microRNA secondary structure and sequence conservation
Identifiers
Symbol mir-451
Rfam RF00722
miRBase family MIPF0000148
HUGO MIR451
OMIM 612071
Other data
RNA type microRNA
Domain(s) Eukaryota; Vertebrata
SO {{{SO}}}

In molecular biology mir-451 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-451 regulates the drug-transporter protein P-glycoprotein, potentially promoting resistance to the chemotherapy drug Paclitaxel.[1]

Applications[edit]

A proof-of-concept experiment has shown that miR-451, as well as mir-126 and mir-150, could be using in forensic science to distinguish between blood and saliva samples.[2] This is made possible by different miRNA profiles of miRNAs in the different tissue types.[2]

References[edit]

  1. ^ van Jaarsveld, MT; Helleman, J; Berns, EM; Wiemer, EA (August 2010). "MicroRNAs in ovarian cancer biology and therapy resistance.". The international journal of biochemistry & cell biology. 42 (8): 1282–90. doi:10.1016/j.biocel.2010.01.014. PMID 20083225. 
  2. ^ a b Courts, C; Madea, B (Aug 9, 2011). "Specific Micro-RNA Signatures for the Detection of Saliva and Blood in Forensic Body-fluid Identification.". Journal of forensic sciences. 56 (6): 1464–70. doi:10.1111/j.1556-4029.2011.01894.x. PMID 21827476. 

Further reading[edit]


External links[edit]