mir-BART2 microRNA precursor family

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mir-BART2 microRNA precursor family
RF00364.jpg
Predicted secondary structure and sequence conservation of mir-BART2
Identifiers
Symbol mir-BART2
Rfam RF00364
miRBase MI0001068
Other data
RNA type Gene; miRNA
Domain(s) Viruses
GO 0035195 0035068
SO 0001244
PDB structures PDBe

The mir-BART2 microRNA precursor found in Human herpesvirus 4 (Epstein-Barr virus) and Cercopithicine herpesvirus 15. mir-BART2 is expressed in all stages of infection but expression is significantly elevated in the lytic stage. In Epstein-Barr virus, mir-BART2 is found in the intronic regions of the BART (Bam HI-A region rightward transcript) gene whose function is unknown. mir-BART2 is thought to target the virally encoded DNA polymerase BALF5 for degradation. The mature sequence is excised from the 5' arm of the hairpin.[1]

References[edit]

  1. ^ Pfeffer, S; Zavolan M; Grasser FA; Chien M; Russo JJ; Ju J; John B; Enright AJ; Marks D; Sander C; Tuschl T (2004). "Identification of Virus-Encoded MicroRNAs". Science. 304 (5671): 734–736. doi:10.1126/science.1096781. PMID 15118162. 

External links[edit]