In the south, Route 376 begins at Route 265 and heads northeast as a four-lane highway. It proceeds uneventfully through generally rural land until curving towards the northwest. Entering a more developed area of Branson, the highway turns east and passes the Celebration City theme park. After a series of slight north–south curves, it comes to an end at Route 76. Past the terminus of Route 376, the road continues as the Shepherd of the Hills Expressway.