Mitchell Siporin was born in New York City to Hyman, a truck driver, and Jennie Siporin, both immigrants from Poland, and grew up in Chicago. He did illustrations for Esquire and other magazines. Beginning in the mid-1930s, Siporin worked as a painter for the Illinois Art Project through the Works Progress Administration. Together with Edward Millman, he painted "the largest single mural project awarded for a post office by the Section of Fine Arts" in the Central Post Office in St Louis, Missouri. He married Miriam Tane in Manhattan to November 9, 1945. From 1946 to 1949, he served in the army in North Africa and Italy. In 1949, he won the Prix de Rome in painting.
Additional works by Siporin can be found in the Art Institute of Chicago, the Metropolitan Museum of Art, the Whitney Museum of American Art, the Museum of Modern Art in New York City and Albert G. Lane Technical High School in Chicago.
- Ted Rall, Attitude: the new subversive political cartoonists, Syracuse, New York: Nantier Beall Minoustchine Publishing, 2002 
- Oakton Community College biography
- 1930 United States Federal Census
- Abram Leon Sachar, Brandeis University: A Host at Last, Waltham, Massachusetts: Brandeis University Press, 1995, p. 157 
- "Mitchell Siporin | Artists | Modernism in the New City: Chicago Artists, 1920-1950". www.chicagomodern.org. Retrieved 2018-06-11.
- New York City, Marriage Indexes, 1907-1995
- Rachel Rosenfield Lafo, Painting in Boston, 1950-2000, Amherst, Massachusetts: University of Massachusetts Press, 2002, p. 204 
- Irving Cutler, The Jews of Chicago: From Shtetl to Suburb, Champaign, Illinois: University of Illinois Press, 1996, p. 146 
- "Mitchell Siporin | The Art Institute of Chicago". www.artic.edu. Retrieved 2018-06-11.
- "Albert G. Lane Technical High School". Chicago Historic Schools. Retrieved 21 August 2015.
- "51st Annual Exhibition" (PDF). Art Institute of Chicago. Retrieved 3 February 2015.