Mitochondrial ferritin

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FTMT
Mitochondrial Ferritin.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FTMT, MTF, Mitochondrial ferritin, ferritin mitochondrial
External IDs MGI: 1914884 HomoloGene: 110661 GeneCards: FTMT
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_177478

NM_026286

RefSeq (protein)

NP_803431

NP_080562.2
NP_080562

Location (UCSC) Chr 5: 121.85 – 121.85 Mb Chr 18: 52.33 – 52.33 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial ferritin is a ferroxidase enzyme that in humans is encoded by the FTMT gene.[3]

It is classified as a metal-binding protein which is located within the mitochondria. After the protein is taken up by the mitochondria it can be processed into a mature protein and assemble functional ferritin shells.

Structure[edit]

Its structure was determined at 1.70 Å through the use of X-ray diffraction and contains 182 residues. It is 67% helical. The Ramachandran plot shows that the structure of mitochondrial ferritin is mainly alpha helical with a low prevalence of beta sheets.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Levi S, Corsi B, Bosisio M, Invernizzi R, Volz A, Sanford D, Arosio P, Drysdale J (July 2001). "A human mitochondrial ferritin encoded by an intronless gene". J. Biol. Chem. 276 (27): 24437–40. doi:10.1074/jbc.C100141200. PMID 11323407. 

Further reading[edit]