Mitochondrial ferritin

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
FTMT
Mitochondrial Ferritin.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFTMT, MTF, Mitochondrial ferritin, ferritin mitochondrial
External IDsOMIM: 608847 MGI: 1914884 HomoloGene: 110661 GeneCards: FTMT
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for FTMT
Genomic location for FTMT
Band5q23.1Start121,851,882 bp[1]
End121,852,833 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_177478

NM_026286

RefSeq (protein)

NP_803431

NP_080562

Location (UCSC)Chr 5: 121.85 – 121.85 MbChr 18: 52.33 – 52.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial ferritin is a ferroxidase enzyme that in humans is encoded by the FTMT gene.[5]

It is classified as a metal-binding protein which is located within the mitochondria. After the protein is taken up by the mitochondria it can be processed into a mature protein and assemble functional ferritin shells.

Structure[edit]

Its structure was determined at 1.70 Å through the use of X-ray diffraction and contains 182 residues. It is 67% helical. The Ramachandran plot shows that the structure of mitochondrial ferritin is mainly alpha helical with a low prevalence of beta sheets.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181867 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024510 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Levi S, Corsi B, Bosisio M, Invernizzi R, Volz A, Sanford D, Arosio P, Drysdale J (July 2001). "A human mitochondrial ferritin encoded by an intronless gene". J. Biol. Chem. 276 (27): 24437–40. doi:10.1074/jbc.C100141200. PMID 11323407.

Further reading[edit]