|By mouth (0.5% solution)|
|Metabolism||Extensive liver (sulfoxidation); first pass effect|
|Biological half-life||6.3 hours (mitratapide), up to 44.7 hours (metabolites)|
|Chemical and physical data|
|Molar mass||717.28 g/mol|
|3D model (JSmol)|
Mitratapide is a veterinary drug for the treatment of overweight and obese dogs sold under the brand name Yarvitan. Its mechanism of action involves inhibition of microsomal triglyceride transfer protein (MTP) which is responsible for the absorption of dietary lipids. Clinical study also suggests that mitratapide may help to reverse insulin resistance in dogs.
Mitratapide (under the brand name Yarvitan) was authorized for use in the EU by the European Medicines Agency for helping weight loss in dogs, but it has since been withdrawn from the market in the EU.
- "Yarvitan 5 mg/ml Oral Solution for Dogs. Summary of Product Characteristics" (PDF). www.ema.europa.eu. Retrieved 27 August 2016.
- "Yarvitan (mitratapide). Scientific Discussion" (PDF). www.ema.europa.eu. Retrieved 27 August 2016.
- Mitratapide, vetstream.com
- Dobenecker, B; De Bock, M; Engelen, M; Goossens, L; Scholz, A; Kienzle, E (2009). "Effect of mitratapide on body composition, body measurements and glucose tolerance in obese Beagles". Veterinary research communications. 33 (8): 839–47. PMC . PMID 19544001. doi:10.1007/s11259-009-9232-5.
- German, AJ (20 October 2016). "Weight management in obese pets: the tailoring concept and how it can improve results". Acta veterinaria Scandinavica. 58 (Suppl 1): 57. PMC . PMID 27766974. doi:10.1186/s13028-016-0238-z.
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