He was a leader fighting with the Tokugawa forces (the eastern army) at the Siege of Osaka. In 1615, the shogunate moved his fief from Kariya Domain in Mikawa Province to Koriyama Domain in Yamato Province (60,000 koku); then in 1619, his fief was transferred to Fukuyama Domain in Bingo Province (100,000 koku). In 1638, he led forces in the shogunate army which put down the Shimabara Rebellion in Kyushu.
In 1651, he died at Fukuyama Castle at the age of 88. His remains were interred at Kenchu-ji, the Mizuno family temple near Fukuyama Castle.
The line of his direct descendants ended in 1698. In 1919, Katsushige was posthumously elevated to the lower third rank of the Imperial Court.
- Papinot, Jacques Edmond Joseph. (1906). Dictionnaire d’histoire et de géographie du Japon; Papinot, (2003). "Mizuno" at Nobiliare du Japon, pp. 35-36; retrieved 2013-5-25.
- Turnbull, Stephen. (2012). Osaka 1615: The last battle of the samurai, p. 79.
- Takekosh, Yosaburo. (2005). The economic aspects of the history of the civilization of Japan, Vol. 2, P. 96.