In the Edo period, the Mizuno clan produced many men who were fudai daimyo serving the Tokugawa shogun, as well as countless families of hatamoto. Lady Odai, Tokugawa Ieyasu's mother, was the daughter of a Mizuno; specifically, Mizuno Tadamasa of Kariya Castle.
The late Edo-era political reformer Mizuno Tadakuni was a descendant of this clan.
The clan ruled over the short-lived Ogawa Domain.
- Bolitho, Harold. (1974). Treasures among Men: The Fudai Daimyo in Tokugawa Japan. New Haven: Yale University Press.
- (Japanese) "Mizuno-shi" on Harimaya.com (14 March 2008)
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