Mizuo–Nakamura phenomenon

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The Mizuo–Nakamura Phenomenon is a phenomenon observed in Oguchi's disease.[1] It was named after Gentaro Mizuo (1876–1913) and Bunpei Nakamura (1886–1969), Japanese ophthalmologists.

Oguchi disease is characterized by a golden-brown fundus with a yellow-gray 'metallic' sheen in the light-adapted state. After complete dark adaptation (3 to 12 hours), the fundus appears normal, and this disappearance of the shiny, yellow, fundus reflex is called the Mizuo–Nakamura phenomenon.


  1. ^ Takada, M.; Otani, A.; Ogino, K.; Yoshimura, N. (2011). "Spectral-Domain Optical Coherence Tomography Findings in the Mizuo–Nakamura Phenomenon of Oguchi Disease". Retina. 31 (3): 626–628. doi:10.1097/IAE.0b013e318206cd52. PMID 21336075.