He started his career as an assistant director, and made his debut as a director with the 2005 film Zeher which was a moderate success. He followed it up with Kalyug, which was both a critical and commercial success. His third film Woh Lamhe (2006) did well and received critical acclaim.
His next film Awarapan (2007) was both a critical and commercial success. It was a copy of the Korean film 'A Bittersweet Life' from 2005. Ironically, Mohit, in an interview given to Radio Sargam, said, "I am very critical about my own work. I would never ever go out and say that I have made a masterpiece. I just give my best and hope that it's good enough." His preceding film Crook, based on the racial attacks on Indian students in Australia was released in 2010. Murder 2, which turned out to be a Blockbuster, a sequel to the 2004 film Murder was released on 8 July 2011.
In 2013, he directed "Aashiqui 2" which was a blockbuster. In 2014, he directed "Ek Villain" which ran successfully and went past the 1 billion mark at box office.