Molsidomine

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Molsidomine
Molsidomine.svg
Names
IUPAC name
1-Ethoxy-N-(3-morpholino-5-oxadiazol-3-iumyl)methanimidate
Identifiers
25717-80-0 YesY
ATC code C01DX12
ChEMBL ChEMBL1256353 N
ChemSpider 4090 YesY
Jmol-3D images Image
KEGG D01320 YesY
PubChem 5353788
UNII D46583G77X YesY
Properties
C9H14N4O4
Molar mass 242.23 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Molsidomine is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.[1]

Release of nitric oxide[2][edit]

Activation of molsidomine.svg








Chemistry[edit]

Molsidomine as well as linsidomine are sydnone imines, a class of mesoionic heterocyclic aromatic chemical compounds.

See also[edit]

References[edit]

  1. ^ Rosenkranz, B.; Winkelmann, B. R.; Parnham, M. J. (1996). "Clinical pharmacokinetics of molsidomine". Clinical pharmacokinetics 30 (5): 372–384. doi:10.2165/00003088-199630050-00004. PMID 8743336.  edit
  2. ^ Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. p. 558. ISBN 3-8047-1763-2.