Monkeypox

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Monkeypox
Monkeypox.jpg
The rash of monkeypox
Specialty Infectious disease
Symptoms Fever, headache, muscle pains, blistering rash, swollen lymph nodes[1]
Usual onset 5-21 days post exposure[1]
Duration 2 to 5 weeks[1]
Causes Monkeypox virus[2]
Diagnostic method Testing for viral DNA[3]
Differential diagnosis Chickenpox, smallpox[4]
Prevention Smallpox vaccine[3]
Medication Cidofovir[4]
Frequency Rare[2]
Deaths Up to 10%[1]

Monkeypox is an infectious disease caused by the monkeypox virus.[2] Symptoms begin with fever, headache, muscle pains, swollen lymph nodes, and feeling tired.[1] This is followed by a rash that forms blisters and crusts over.[1] The time from exposure to onset of symptoms is around 10 days.[1] The duration of symptoms is typically 2 to 5 weeks.[1]

Monkeypox may be spread from handling bush meat, an animal bite or scratch, body fluids, contaminated objects, or close contact with an infected person.[5] The virus is believed to normally circulate among certain rodents in Africa.[5] Diagnosis can be confirmed by testing a lesion for the virus's DNA.[3] The disease can appear similar to chickenpox.[4]

The smallpox vaccine is believed to prevent infection.[3] Cidofovir may be useful as treatment.[4] The risk of death in those infected is up to 10%.[1]

The disease mostly occurs in Central and West Africa.[6] It was first identified in 1958 among laboratory monkeys.[6] The first cases in humans were found in 1970 in the Democratic Republic of the Congo.[6] An outbreak that occurred in the United States in 2003 was traced to a pet store where imported Gambian rodents were sold.[3]

Signs and symptoms[edit]

An image of the rash of monkeypox

Monkeypox is similar to smallpox, although it is often milder.

Limited person-to-person spread of infection has been reported in disease-endemic areas in Africa. Case-fatality ratios in Africa have ranged from 1 to 10%.[7]

Cause[edit]

Monkeypox virus[edit]

Monkeypox virus
Monkeypox.gif
Virus classification
Group: Group I (dsDNA)
Order: Unassigned
Family: Poxviridae
Subfamily: Chordopoxvirinae
Genus: Orthopoxvirus
Type species
Vaccinia virus
Species

Monkeypox virus

Monkeypox virus causes the disease in both humans and animals. It was first identified in 1958 as a pathogen of crab-eating macaque monkeys (Macaca fascicularis) being used as laboratory animals. The crab-eating macaque is often used for neurological experiments. Monkeypox virus is an Orthopoxvirus, a genus of the family Poxviridae that contains other viral species that target mammals. The virus is found mainly in tropical rainforest regions of Central and West Africa.

The virus was first discovered in monkeys (hence the name) in 1958, and in humans in 1970. Between 1970 and 1986, over 400 cases in humans were reported. Small viral outbreaks with a death rate in the range of 10% and a secondary human-to-human infection rate of about the same amount occur routinely in equatorial Central and West Africa.[8] The primary route of infection is thought to be contact with the infected animals or their bodily fluids.[8] The first reported outbreak in the United States occurred in 2003 in the Midwestern states of Illinois, Indiana, and Wisconsin, with one occurrence in New Jersey. The outbreak was traced to a prairie dogs infected from an imported Gambian pouch rat. No deaths occurred.

The virus can spread both from animal-to-human and from human-to-human. Infection in the former can occur via an animal bite or by direct contact with an infected animal’s bodily fluids. The virus can spread in the latter both by respiratory (airborne) contact and by contact with an infected person's bodily fluids. Risk factors for transmission include sharing a bed or room, or using the same utensils as an infected patient. An increased transmission risk is associated with factors involving introduction of virus to the oral mucosa.[9] The incubation period is 10–14 days. Prodromal symptoms include swelling of lymph nodes, muscle pain, headache, and fever prior to the emergence of the rash. The rash is usually only present on the trunk, but has the capacity to spread to the palms and soles of the feet, occurring in a centrifugal distribution. The initial macular lesions exhibit a papular, then vesicular and pustular appearance.[9]

Reservoir[edit]

In addition to monkeys, reservoirs for the virus are found in Gambian pouched rats (Cricetomys gambianus), dormice (Graphiurus spp.) and African squirrels (Heliosciurus, and Funisciurus). The use of these animals as food may be an important source of transmission to humans.[citation needed]

Prevention[edit]

Vaccination against smallpox is assumed to provide protection against human monkeypox infection, because they are closely related viruses and the vaccine protects animals from experimental lethal monkeypox challenge.[10] This has not been conclusively demonstrated in humans, because routine smallpox vaccination was discontinued following the apparent eradication of smallpox and owing to safety concerns with the vaccine.

Smallpox vaccine has been reported to reduce the risk of monkeypox among previously vaccinated persons in Africa. The decrease in immunity to poxviruses in exposed populations is a factor in the prevalence of monkeypox. It is attributed both to waning cross-protective immunity among those vaccinated before 1980 when mass smallpox vaccinations were discontinued, and to the gradually increasing proportion of unvaccinated individuals.[9] The United States Centers for Disease Control and Prevention (CDC) recommends that persons investigating monkeypox outbreaks and involved in caring for infected individuals or animals should receive a smallpox vaccination to protect against monkeypox. Persons who have had close or intimate contact with individuals or animals confirmed to have monkeypox should also be vaccinated.

The CDC does not recommend pre-exposure vaccination for unexposed veterinarians, veterinary staff, or animal control officers, unless such persons are involved in field investigations.

Treatment[edit]

Currently, no treatment for monkeypox has been shown to be effective or safe. The people who have been infected can be vaccinated up to 14 days after exposure.

Epidemiology[edit]

Monkeypox as a disease in humans was first associated with an illness in the Democratic Republic of the Congo (formerly Zaire), in the town of Basankusu, Équateur Province, in 1970.[11] A second outbreak of human illness was identified in DRC/Zaire in 1996–1997. In 2003, a small outbreak of human monkeypox in the United States occurred among owners of pet prairie dogs.[12] The outbreak originated from Villa Park, Illinois, outside of Chicago, when an exotic animal dealer kept young prairie dogs in close proximity to an infected Gambian pouched rat (Cricetomys gambianus) recently imported from Accra, Ghana. Seventy-one people were reportedly infected, in which no fatalities occurred.

A second African focus of infection has been discovered in Sudan. No infected patients died.[13]

2003 U.S. outbreak[edit]

In May 2003, a young child became ill with fever and rash after being bitten by a prairie dog purchased at a local swap meet near Milwaukee, Wisconsin.[14] In total, 71 cases of monkeypox were reported through June 20, 2003. All cases were traced to Gambian rats imported by a Texas exotic animal distributor, from Accra, Ghana, in April, 2003. No deaths resulted.[15] Electron microscopy and serologic studies were used to confirm that the disease was human monkeypox.

Patients typically experienced prodromal symptoms of fever, headaches, muscle aches, chills, and drenching sweats. Roughly one-third of patients had nonproductive coughs. This prodromal phase was followed 1–10 days later by the development of a papular rash that typically progressed through stages of vesiculation, pustulation, umbilication, and crusting. In some patients, early lesions had become ulcerated. Rash distribution and lesions occurred on head, trunk, and extremities; many of the patients had initial and satellite lesions on palms, soles, and extremities. Rashes were generalized in some patients. After onset of the rash, patients generally manifested rash lesions in different stages. All patients reported direct or close contact with prairie dogs, later found to be infected with the monkeypox virus.[16]

2017 Nigeria outbreak[edit]

Monkeypox has been reportedly spread around southeast and south Nigeria. Some states and the federal government of Nigeria are currently seeking a way to contain it, as well as find a cure for the infected ones. It has spread to Lagos, Akwa Ibom, Bayelsa, Cross River, Delta, Ekiti, Enugu, Imo, Ibadan, Nasarawa, Niger, Rivers, and the federal capital territory.

2018 United Kingdom cases[edit]

In September 2018, the United Kingdom's first case of monkeypox was recorded. The patient, a Nigerian national, is believed to have contracted monkeypox in Nigeria before travelling to the United Kingdom.[17] According to Public Health England, the patient was staying in a naval base in Cornwall before being moved to Royal Free Hospital's expert infectious disease unit. To ensure that the disease does not spread, experts are contacting anyone who made contact with the patient since he contracted the disease.[18] A second case was confirmed in the town of Blackpool.[19][20]

References[edit]

  1. ^ a b c d e f g h i "Signs and Symptoms Monkeypox". CDC. 11 May 2015. Archived from the original on 15 October 2017. Retrieved 15 October 2017. 
  2. ^ a b c "About Monkeypox". CDC. 11 May 2015. Archived from the original on 15 October 2017. Retrieved 15 October 2017. 
  3. ^ a b c d e "2003 U.S. Outbreak Monkeypox". CDC. 11 May 2015. Archived from the original on 15 October 2017. Retrieved 15 October 2017. 
  4. ^ a b c d McCollum, AM; Damon, IK (January 2014). "Human monkeypox". Clinical Infectious Diseases. 58 (2): 260–7. doi:10.1093/cid/cit703. PMID 24158414. 
  5. ^ a b "Transmission Monkeypox". CDC. 11 May 2015. Archived from the original on 15 October 2017. Retrieved 15 October 2017. 
  6. ^ a b c "Monkeypox". CDC. 11 May 2015. Archived from the original on 15 October 2017. Retrieved 15 October 2017. 
  7. ^ Hutin YJ, Williams RJ, Malfait P, et al. (2001). "Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997". Emerging Infect. Dis. 7 (3): 434–8. doi:10.3201/eid0703.010311. PMC 2631782Freely accessible. PMID 11384521. Archived from the original on 2010-08-04. 
  8. ^ a b Meyer, H.; Mathilde Perrichot; Markus Stemmler; Petra Emmerich; Herbert Schmitz; Francis Varaine; Robert Shungu; Florimond Tshioko; Pierre Formenty (2002). "Outbreaks of Disease Suspected of Being Due to Human Monkeypox Virus Infection in the Democratic Republic of Congo in 2001". Journal of Clinical Microbiology. American Society for Microbiology. 40 (8): 2919–2921. doi:10.1128/JCM.40.8.2919-2921.2002. PMC 120683Freely accessible. PMID 12149352. 
  9. ^ a b c Kantele A, Chickering K, Vapalahti O, Rimoin AW (2016). "Emerging diseases—the monkeypox epidemic in the Democratic Republic of the Congo". Clinical Microbiology and Infection. 22 (8): 658–659. doi:10.1016/j.cmi.2016.07.004. 
  10. ^ Marriott KA, Parkinson CV, Morefield SI, Davenport R, Nichols R, Monath TP (2008). "Clonal vaccinia virus grown in cell culture fully protects monkeys from lethal monkeypox challenge". Vaccine. 26 (4): 581–8. doi:10.1016/j.vaccine.2007.10.063. PMID 18077063. 
  11. ^ Ladnyj ID, Ziegler P, Kima E. "A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo". Bull World Health Organ. 46: 593–7. PMC 2480792Freely accessible. PMID 4340218. 
  12. ^ "What You Should Know About Monkeypox" (PDF). Fact Sheet. Centers for disease control and prevention. 2003-06-12. Archived (PDF) from the original on 2008-06-25. Retrieved 2008-03-21. 
  13. ^ Damon IK, Roth CE, Chowdhary V (2006). "Discovery of monkeypox in Sudan". N. Engl. J. Med. 355 (9): 962–3. doi:10.1056/NEJMc060792. PMID 16943415. Archived from the original on 2007-01-23. 
  14. ^ Anderson MG, Frenkel LD, Homann S, and Guffey J. (2003), "A case of severe monkeypox virus disease in an American child: emerging infections and changing professional values"; Pediatr Infect Dis J;22(12): 1093–1096; discussion 1096–1098.
  15. ^ "Medscape Monkeypox Review". Bcbsma.medscape.com. Retrieved 2013-03-22. 
  16. ^ CDC, Morbidity and Mortality Weekly Report. Atlanta, Georgia. (MMWR) July 11, 2003. (52) 27; 642-646.
  17. ^ "First ever case of monkeypox recorded in the UK". the Guardian. 8 September 2018. Retrieved 8 September 2018. 
  18. ^ "Monkeypox case in England". gov.uk. 8 September 2018. Retrieved 8 September 2018. 
  19. ^ "Blackpool monkeypox case confirmed as second in UK". BBC News. 11 September 2018. Retrieved 11 September 2018. 
  20. ^ Vaughan, Aisling; Aarons, Emma; Astbury, John; Balasegaram, Sooria; Beadsworth, Mike; Beck, Charles R; Chand, Meera; O’Connor, Catherine; Dunning, Jake (2018-09-20). "Two cases of monkeypox imported to the United Kingdom, September 2018". Eurosurveillance. 23 (38). doi:10.2807/1560-7917.es.2018.23.38.1800509. ISSN 1560-7917. 

External links[edit]

Classification