Monocarboxylate transporter 2

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
SLC16A7
Identifiers
AliasesSLC16A7, MCT2, solute carrier family 16 member 7
External IDsMGI: 1330284 HomoloGene: 20990 GeneCards: SLC16A7
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SLC16A7
Genomic location for SLC16A7
Band12q14.1Start59,596,067 bp[1]
End59,789,855 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270622
NM_001270623
NM_004731

NM_011391
NM_001358496
NM_001358915

RefSeq (protein)

NP_001257551
NP_001257552
NP_004722

NP_035521
NP_001345425
NP_001345844

Location (UCSC)Chr 12: 59.6 – 59.79 MbChr 10: 125.22 – 125.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a protein that in humans is encoded by the SLC16A7 gene.[5] MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Both Northern blot analysis and inspection of the human expressed sequence tag (EST) database suggest relatively little expression of MCT2 in human tissues. As well, the sequence of MCT2 is far less conserved across species than that of MCT1 or MCT4 and there also appear to be considerable species differences in the tissue expression profile of this isoform.

Of the four known mammalian lactate transporters (MCTs 1-4), MCT2 harbors the highest affinity for lactate. [6] In parallel, MCT2 gene transcription has been demonstrated to respond with high-sensitivity to hypoxia, intracellular pH, and, to lactate. [7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118596 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020102 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Apr 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722.
  6. ^ Halestrap AP (Jan 2012). "The monocarboxylate transporter family--Structure and functional characterization". IUBMB Life. 64 (1): 1–9. doi:10.1002/iub.573. PMID 22131303.
  7. ^ Caruso JP, Koch BJ, Benson PD, Varughese E, Monterey MD, Lee AE, Dave AM, Kiousis S, Sloan AE, Mathupala SP (Feb 2017). "pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma". Neoplasia. 19 (2): 121–134. doi:10.1016/j.neo.2016.12.011. PMC 5238458. PMID 28092823.

Further reading[edit]