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Monocytosis is an increase in the number of monocytes circulating in the blood.[1] Monocytes are white blood cells that give rise to macrophages and dendritic cells in the immune system.

In humans, monocytosis occurs when there is a sustained rise in monocyte counts greater than 800/mm3 to 1000/mm3.[2]

Monocytosis has sometimes been called mononucleosis,[3] but that name is usually reserved specifically for infectious mononucleosis.


Monocytosis often occurs during chronic inflammation. Diseases that produce such a chronic inflammatory state:[citation needed]

During these stages of extreme inflammation, monocytosis can damage tissues because it increases the activation of the immune response and prevents the inflammation from subsiding which is seen in cases where sepsis occurs.[4]


  • Blood Test (CBC) (Normal range of Monocytes: 1-10%) (Normal range in males: 0.2-0.8 x 103/microliter)[citation needed]
  • Blood test checking for monocytosis (Abnormal ranges: >10%) (Abnormal range in males: >0.8 x 103/microliter)[citation needed]


Ceftriaxone if there is typhoid fever and levofloxacin or moxifloxacin. Gentamicin and doxycyclin if brucellosis.[citation needed]


  1. ^ "monocytosis" at Dorland's Medical Dictionary
  2. ^ Rice, Lawrence; Jung, Moonjung (2018). "Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia". In Hoffman, Ronald; Benz, Edward J.; Heslop, Helen; Silberstein, Leslie E.; Weitz, Jeffrey; Anastasi, John (eds.). Hematology. pp. 675–681. doi:10.1016/B978-0-323-35762-3.00048-2. ISBN 978-0-323-35762-3.
  3. ^ Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier.
  4. ^ Dutta, Partha; Nahrendorf, Matthias (15 October 2014). "Regulation and consequences of monocytosis". Immunological Reviews. 262 (1): 167–168. doi:10.1111/imr.12219. PMC 4203415. PMID 25319334.

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