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3-Iodotyrosine zwitterion 3D ball.png
IUPAC name
(2S)-2-Amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
Other names
Monoiodotyrosine; MIT[1]
3D model (JSmol)
ECHA InfoCard 100.000.677 Edit this at Wikidata
MeSH Monoiodotyrosine
Molar mass 307.087 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

3-Iodotyrosine is an intermediate in the synthesis of thyroid hormones which is derived from iodination of tyrosine at the meta-position of the benzene ring. One unit can combine with diiodotyrosine to form triiodothyronine, as occurs in the colloid of the thyroid follicle. Two units can combine to form 3,3'-diiodothyronine.

3-Iodotyrosine is a reversible inhibitor of the enzyme tyrosine hydroxylase.[2]

Relevance in dopamine studies[edit]

3-Iodotyrosine, a pathway inhibitor in the synthesis of the neurotransmitter dopamine, was used to determine the effects of decreased dopamine levels in social spacing of Drosophila melanogaster. 3-4 day old flies that were fed 3-iodotyrosine for 24 hours were shown to have altered dopamine levels.[3]


  1. ^ Tietze F, Kohn LD, Kohn AD, et al. (March 1989). "Carrier-mediated transport of monoiodotyrosine out of thyroid cell lysosomes". J. Biol. Chem. 264 (9): 4762–5. PMID 2925666.
  2. ^ Richelson E (November 1976). "Properties of tyrosine hydroxylation in living mouse neuroblastoma clone N1E-115". Journal of Neurochemistry. 27 (5): 1113–8. doi:10.1111/j.1471-4159.1976.tb00317.x. PMID 12170597.
  3. ^ Fernandez, Robert W.; Akinleye, Adesanya A.; Nurilov, Marat; Feliciano, Omar; Lollar, Matthew; Aijuri, Rami R.; O'Donnell, Janis M.; Simon, Anne F. (2017-08-01). "Modulation of social space by dopamine in Drosophila melanogaster, but no effect on the avoidance of the Drosophila stress odorant". Biology Letters. 13 (8): 20170369. doi:10.1098/rsbl.2017.0369. ISSN 1744-9561. PMC 5582115. PMID 28794277.