Methylamine-corrinoid protein Co-methyltransferase

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Methylamine-corrinoid protein Co-methyltransferase
Identifiers
EC number 2.1.1.248
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Methylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.248, mtmB (gene), monomethylamine methyltransferase) is an enzyme with systematic name monomethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

methylamine + [Co(I) methylamine-specific corrinoid protein] [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia

This enzyme is involved in methanogenesis from methylamine.

References[edit]

  1. ^ Burke, S.A.; Krzycki, J.A. (1997). "Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". J. Biol. Chem. 272: 16570–16577. doi:10.1074/jbc.272.26.16570. PMID 9195968. 
  2. ^ Burke, S.A.; Lo, S.L.; Krzycki, J.A. (1998). "Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine". J. Bacteriol. 180: 3432–3440. PMC 107300Freely accessible. PMID 9642198. 
  3. ^ Krzycki, J.A. (2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Curr. Opin. Chem. Biol. 8: 484–491. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490. 

External links[edit]