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Mordechai Ish-Shalom (Hebrew: מרדכי איש-שלום), (1902–1991), was an Israeli politician and labor leader. He was mayor of Jerusalem from 1959 to 1965.
Ish-Shalom was born in Lithuania and moved to British Palestine in 1923. His labor career began in the Stonecutters' Union in 1935; he then rose through the ranks of the Histadrut, the Israeli trade union congress.
Ish-Shalom was instrumental in the successful development of Kiryat Wolfson, a five-tower high-rise project constructed in Jerusalem in the 1970s.
Ish-Shalom died at the age of 90. The cause of death was not released.