Mosapramine

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Mosapramine
Mosapramine.svg
Mosapramine3Dan.gif
Systematic (IUPAC) name
1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one
Clinical data
Trade names Cremin (クレミン, JP)
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral (tablets, oral solution)
Legal status
Legal status
  • Rx-only (JP)
Identifiers
CAS Number 89419-40-9 YesY
ATC code N05AX10 (WHO)
PubChem CID 4257
ChemSpider 4107
UNII 04UZQ7O9SJ YesY
KEGG D08235 YesY
Chemical data
Formula C28H35ClN4O
Molar mass 479.057 g/mol
  (verify)

Mosapramine (Cremin) is an atypical antipsychotic used in Japan.[1] It is a potent dopamine antagonist with high affinity to the D2, D3, and D4 receptors,[2] and with moderate affinity for the 5-HT2 receptors.[3]

See also[edit]

References[edit]

  1. ^ Takahashi N, Terao T, Oga T, Okada M. Comparison of risperidone and mosapramine addition to neuroleptic treatment in chronic schizophrenia. Neuropsychobiology. 1999;39(2):81-5. PMID 10072664
  2. ^ Futamura T, Ohashi Y, Yano K, Takahashi Y, Haga K, Fukuda T. The affinities of mosapramine for the dopamine receptor subtypes in human cell lines expressing D2, D3 and D4 receptors. Nippon Yakurigaku Zasshi. (Japanese) 1996 May;107(5):247-53. PMID 8690306
  3. ^ Sumiyoshi T, Suzuki K, Sakamoto H, Yamaguchi N, Mori H, Shiba K, Yokogawa K. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12(1):57-64. doi:10.1016/0893-133X(94)00064-7 PMID 7766287