In 1991 he became the commander of the Old City border police, and in 1996 became the commander of the Lakhish Region.
He became the commander of the police's Southern Command in October 2002 and from there appointed general commissioner on August 1, 2004. During this time, he oversaw the preparation and participation of the police in Israel's unilateral disengagement plan of the summer of 2005. Karadi was criticized for some of the police suppressive tactics used against protesters.
Karadi resigned his position on February 18, 2007, following the publicity of the findings of the Zeiler Commission, and continued his post until May 1, 2007, when Dudi Cohen, the next general commissioner, assumed office.
- Fendel, Hillel. "Police Commissioner Moshe Karadi Resigns". Retrieved 2008-04-26.