Motexafin gadolinium

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Motexafin gadolinium
Motexafin gadolinium 3D sticks.png
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
ChEBI
Chemical and physical data
Formula C52H72GdN5O14
Molar mass 1148.403 g/mol
3D model (Jmol)
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Motexafin gadolinium (proposed tradename Xcytrin) is an inhibitor of thioredoxin reductase and ribonucleotide reductase. It has been proposed as a possible chemotherapeutic agent in the treatment of brain metastases.[1]

History[edit]

On May 9, 2006, a New Drug Application was submitted to the United States Food and Drug Administration (FDA) by Pharmacyclics, Inc.[2]

On December 2007, the FDA issued a not approvable letter for motexafin gadolinium.[3]

References[edit]

  1. ^ Richards G, Mehta M (2007). "Motexafin gadolinium in the treatment of brain metastases". Expert opinion on pharmacotherapy. 8 (3): 351–9. doi:10.1517/14656566.8.3.351. PMID 17266469. 
  2. ^ Pharmacyclics, Inc. press release - Pharmacyclics to Submit New Drug Application for Xcytrin for Treatment of Lung Cancer Patients With Brain Metastases
  3. ^ Pharmacyclics, Inc. press release - Pharmacyclics Receives Non-Approvable Letter from the FDA for Xcytrin for the Treatment of Lung Cancer Brain Metastases