Mothers against decapentaplegic homolog 5

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SMAD5
PDB 1khu EBI.jpg
Identifiers
Aliases SMAD5, DWFC, JV5-1, MADH5, SMAD family member 5
External IDs OMIM: 603110 MGI: 1328787 HomoloGene: 4313 GeneCards: 4090
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005903
NM_001001419
NM_001001420

NM_001164041
NM_001164042
NM_008541

RefSeq (protein)

NP_001001419.1
NP_001001420.1
NP_005894.3

NP_001157513.1
NP_001157514.1
NP_032567.1

Location (UCSC) Chr 5: 136.13 – 136.19 Mb Chr 13: 56.7 – 56.74 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.[3]

SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic", based on a tradition of such unusual naming within the gene research community.[4] It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135. 
  4. ^ "Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White. psmag.com