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Mothers against decapentaplegic homolog 5

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This is an old revision of this page, as edited by 171.66.209.5 (talk) at 23:09, 30 October 2014 (A typo - this protein is encoded by the SMAD5 gene, not the SAMD5 gene (which was what was written before). SAMD5 gene exists, but little is know about it, and it is on a different chromosome from the SMAD5 gene.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

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Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.[1]

SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.

References

  1. ^ Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135.{{cite journal}}: CS1 maint: multiple names: authors list (link)


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