The song follows a man who is forced to sleep in the doghouse after coming home late at night and not being allowed into his house by his wife. In many respects, the song typified Williams' uncanny ability to express in a humorous way the aspects of everyday life that listeners could relate to - and rarely heard on the radio. As fiddler Jerry Rivers later recalled, Hank's novelty songs "weren't novelty - they were serious, not silly, and that's why they were much better accepted and better selling. 'Move It on Over' hits right home, 'cause half of the people he was singing to were in the doghouse with the ol' lady."
"Move It on Over was Williams' first Billboard hit, got him a write up in The Alabama Journal, and generated the first serious money the singer had ever seen in his life. It also earned him a spot on the coveted Louisiana Hayride, the training ground for the Grand Ole Opry.