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Mr. E may refer to:
- Mister E, a DC Comics character and member of The Trenchcoat Brigade
- Mister E (Timely Comics), a Timely Comics (now Marvel Comics) character
- Mark Oliver Everett, lead vocalist and guitarist for Eels
- Nathan Ellery, a DC comics character who masterminded the murder of Alec Holland
|This disambiguation page lists articles associated with the title Mr. E.
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