Mr. Flutesnoot is a chemistry professor (he has also been shown teaching music and history as well). Although to a lesser level than Hiram Lodge and Mr. Weatherbee, he is sometimes the victim of Archie's ever-present accidents (in particular when Archie blows up the school's chemistry lab).
Occasionally, Mr. Flutesnoot will run into trouble when dealing with his scientific finds. In one comic, Moose gains the ability to predict the weather from sunspot activity. The sunspot effect wears off right as Moose predicts sunny weather for the next day's meteorological picnic, so Flutesnoot makes a fool out of himself when a thunderstorm comes instead.
Another time, Flutesnoot's satellite dish picks up a signal he believes to be of extraterrestrial origin, but he later discovers that the sound is from an audio tape running backwards. However, at the end of the story, there is, in fact, a rock band of aliens singing exactly the same words.
Skinny and aging, Professor Flutesnoot sports an extremely prominent nose (hence his name) and tufts of curly white hair at his temples (but is otherwise bald). Before Professor Flutesnoot appeared, Archie comics featured a similarly designed character named Mr. Fluteweed (a music teacher). Professor Flutesnoot may have evolved from Mr. Fluteweed.