Mucocutaneous zone

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A mucocutaneous zone, or mucocutaneous boundary is a region of the body in which mucosa transitions to skin. Mucocutaneous zones occur in animals, at the body orifices.

In humans, mucocutaneous zones are found at the lips, nostrils, conjunctivae, urethra, vagina (in females), foreskin (in males), and anus.

At a mucocutaneous junction, epithelium transitions to epidermis, lamina propria transitions to dermis, and smooth muscle transitions to skeletal muscle.[1] A mucocutaneous zone is often the site of an arterial anastomosis, a watershed area of venous and lymphatic drainage, and sensory (but not motor) nerve overlap.

Winkelmann (1959) reported the mucocutaneous boundary is a "specific erogenous zone with rete ridges where the nerve endings rise closer to the surface".[2]

See also[edit]


  1. ^ Norman Eizenberg, General Anatomy: Principles and Applications (2008), p. 96.
  2. ^ Winkelmann RK. The erogenous zones: their nerve supply and significance. Mayo Clin Proc 1959;34(2):39-47. PMID 13645790