Born in Jerusalem, Nashashibi was educated at St. George's School in Jerusalem, the American University in Cairo and Robert College in Istanbul. In 1936, he returned to Jerusalem to work as an engineer. In 1949, he became the manager of engineering services for the United Nations Relief and Works Agency for Palestinian Refugees. In 1962, he became project manager for the construction of the Kuwait Sewage System. At first, he moved to Lebanon but, in the early 1980s, he moved to California, where he died.
- Twair, Pat McDonnell (1999). "Mufid Nashashibi: 1915–1999". Washington Report on Middle East Affairs. American Educational Trust.