Murid herpesvirus 4

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Murid herpesvirus 4
Virus classification
Group: Group I (dsDNA)
Family: Herpesviridae
Subfamily: Gammaherpesvirinae
Genus: Rhadinovirus
Species: Murid herpesvirus 4 (MuHV 4)

Murid herpesvirus 4 (MuHV 4) is a virus in the genus Rhadinovirus. It is a member of the subfamily Gammaherpesvirinae in the family Herpesviridae. MuHV 4 infects mice via the nasal passages and causes an acute infectious mononucleosis-like syndrome with elevated levels of leukocytes, and shifts in the relative proportion of lymphocytes along with the appearance of atypical mononuclear cells.[1] Murid herpesvirus 4 currently serves as a model for study of human gamma-herpesvirus pathogenesis.[2]

Seven strains of MuHV 4 have been isolated, including the following six:

  • MHV-Šum
  • MHV-60
  • MHV-68
  • MHV-72
  • MHV-76
  • MHV-4556


  1. ^ Jela Mistríková & Július Rajčáni. "Comparison of pathogenic properties of the murid gammaherpesvirus (MuHV 4) strains: a role for immunomodulatory proteins encoded by the left (5'-)end of the genome". Central European Journal of Biology. 3 (1 / March, 2008). doi:10.2478/s11535-008-0002-0. 
  2. ^ Valovicová M, Rezuchorá I, Macáková K, Petrová P, Matis J, Kúdelová M (2006). "Murine gammaherpesvirus (MHV) MK3 gene sequence diversity among 72, 4556, and 68 strains". Virus Genes. 33 (1): 51–8. doi:10.1007/s11262-005-0038-4. PMID 16791419.