Muromegalovirus

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Muromegalovirus
Virus classification
Group: Group I (dsDNA)
Order: Herpesvirales
Family: Herpesviridae
Subfamily: Betaherpesvirinae
Genus: Muromegalovirus
Type Species

Muromegalovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Rodents that belong to the betaherpesvirinae subfamily of herpesviruses serve as natural hosts. There are currently three species in this genus including the type species Murid herpesvirus 1. Diseases associated with this genus include: infected peritoneal macrophages, dendritic cells (DC) and hepatocytes, inducing significant pathology in both the spleen and the liver.[1][2] Murid viruses murid herpesvirus 1 (MuHV-1) and murid herpesvirus 2 (MuHV-2)--previously defined as mouse cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV)--belong to this genus.[3]

Taxonomy[edit]

Group: dsDNA

[2]

Structure[edit]

Viruses in Muromegalovirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 230kb in length.[1]

Genus Structure Symmetry Capsid Genomic Arrangement Genomic Segmentation
Muromegalovirus Spherical Pleomorphic T=16 Enveloped Linear Monopartite

Life Cycle[edit]

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and budding. Rodents serve as the natural host.[1]

Genus Host Details Tissue Tropism Entry Details Release Details Replication Site Assembly Site Transmission
Muromegalovirus Rodents Salivary glands Glycoprotiens Budding Nucleus Nucleus Contact

References[edit]

  1. ^ a b c "Viral Zone". ExPASy. Retrieved 15 June 2015. 
  2. ^ a b ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015. 
  3. ^ Koichi Yamanishi; Arvin, Ann M.; Gabriella Campadelli-Fiume; Edward Mocarski; Moore, Patrick; Roizman, Bernard; Whitley, Richard (2007). Human herpesviruses: biology, therapy, and immunoprophylaxis. Cambridge, UK: Cambridge University Press. ISBN 0-521-82714-0. 

External links[edit]