In television supernatural drama Charmed, season 4 episode 9 "Muse to My Ear", the Charmed Ones must protect the muses from a warlock who is trapping them into a magical ring and using their inspiration to make the Forces of Evil more powerful.
In episode 126 ("Out of Sync") from the animated series Cyberchase, Calliope plays her lyre and she's one of the four Mount Olympus band members with Apollo the Greek god of music (who plays the gong), Himaropa the siren (who plays the horn), and the Beast (who plays the drums).
In the anime series Guilty Crown, main character Inori Yuzuriha is best known for her song Euterpe.
In Supernatural episode "Fan Fiction" Calliope appears as the antagonist.
The muse Clio is a main supporting character in Jodi Taylor's The Chronicles of St. Mary's series - using the name "Mrs. Partridge" as a cover while working as the personal assistant to Dr. Bairstowe. Her true identity as Clio is known only by the series protagonist Dr. Maxwell.
In Daniel Quinn's My Ishmael, the fictional planet Terpischore is a land ravished by dancing, with dancing paralleling the rise of agriculture on Earth. Dancing (in an unspecified manner) speeds up the growth of the natives' "favorite foods".
Terpsichore is a character in the 2007 musical Xanadu, which is based on the 1980 film of the same name. Her part is always played by a man in drag. She was played by Andre Ward in the original Broadway production.
Thalia features in the 1997 Walt Disney Pictures film Hercules, appearing alongside the muses Calliope, Clio, Melpomene and Terpsichore, who collectively serve as a Greek chorus. Portrayed as a short and plump, she has the deepest voice amongst the five Muses depicted and true to nature, often makes the funniest comments. She was voiced by Roz Ryan, who reprised the role in the subsequent TV series.
Thalia is a character in the 2007 musical Xanadu, which is based on the 1980 film of the same name. Her part is always played by a man in drag. She was played by Curtis Holbrook in the original Broadway production.