Muzolimine

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Muzolimine
Muzolimine.png
Clinical data
ATC code
Legal status
Legal status
  • Withdrawn
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
Formula C11H11Cl2N3O
Molar mass 272.13 g/mol
3D model (Jmol)
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Muzolimine is a High-ceiling loop diuretic.[1] It is a pyrazole diuretic which was used for treatment of hypertension but was withdrawn worldwide because of severe neurological side effects.[2]

Synthesis[edit]

Muzolimine synthesis:[3]

Rxn of (1-(3,4-dichlorophenyl)ethyl)hydrazine (1) with ethyl 3-amino-3-ethoxyacrylate (2) leads to a ring-forming two-site reaction and formation of the pyrazoline diuretic agent, muzolimine (3).

References[edit]

  1. ^ Wangemann, P.; Braitsch, R.; Greger, R. (1987). "The diuretic effect of muzolimine". Pflugers Archiv : European journal of physiology. 410 (6): 674–676. PMID 3449804. 
  2. ^ Reyes, A. J.; Leary, W. P. (1993). "Clinicopharmacological reappraisal of the potency of diuretics". Cardiovascular Drugs and Therapy. 7: 23–28. doi:10.1007/BF00877955. PMID 8435374. 
  3. ^ E. Möller et al., DE 2319278 ; eidem, U.S. Patent 3,957,814 (1974, 1976 both to Bayer); eidem, Experientia 33, 382 (1977).