The song was originally recorded from late 1967 to early 1968, but not released until early 1969. The song was co-written by Wonder, Sylvia Moy, and Henry Cosby; Cosby also served as producer of the song.
The song was originally written about Wonder's girlfriend while he was at the Michigan School for the Blind in Lansing, Michigan, and had the title "Oh My Marsha". After they broke up, the lyrics and title were altered to the more general "My Cherie Amour". All the instruments except for the horns and the strings were recorded on November 8, 1967. Then, on November 17 of that year, the horns and strings were added at Golden World Records, one year before it was acquired by Motown. Finally, Wonder's vocals were added on January 15, 1968, but it was not released until January 28, 1969 because at the time of the song's release, Wonder had some vocal problems and had to wait until the problems were gone, so Motown decided to release some songs that Wonder had recorded years before and "My Cherie Amour" was one of them. The song became a #4 hit on both the Billboardpop and R&B singles charts in July 1969. Wonder also released Spanish- and Italian-language versions entitled "Mi Querido Amor" and "My Cherie Amor", respectively.
The song was featured in the 2012 comedy film Silver Linings Playbook as Pat’s and Nikki’s wedding song. It makes Pat have a mental breakdown every time he hears it after having been divorced from his wife.