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Classification and external resources
Specialty Rheumatology
ICD-10 M79.1
ICD-9-CM 729.1
DiseasesDB 22895
MedlinePlus 003178
MeSH D063806

Myalgia, or muscle pain, is a symptom of many diseases and disorders. The most common causes are the overuse or over-stretching of a muscle or group of muscles. Myalgia without a traumatic history is often due to viral infections. Longer-term myalgias may be indicative of a metabolic myopathy, some nutritional deficiencies or chronic fatigue syndrome.


The most common causes of myalgia are overuse, injury or strain. However, myalgia can also be caused by diseases, disorders, medications, or as a response to a vaccination. It is also a sign of acute rejection after heart transplant surgery.

The most common causes are:

  • Injury or trauma, including sprains, hematoma
  • Overuse: using a muscle too much, too often, including protecting a separate injury
  • Chronic tension

Muscle pain occurs with:


Overuse of a muscle is using it too much, too soon and/or too often.[4] Examples are:


The most common causes of myalgia by injury are: sprains and strains.[4]


Multiple sclerosis (neurologic pain interpreted as muscular), Myalgic Encephalomyelitis, Myositis, Lupus erythematosus, Familial Mediterranean fever, Polyarteritis nodosa, Devic's disease, Morphea, Sarcoidosis

Metabolic defect[edit]

Carnitine palmitoyltransferase II deficiency, Conn's syndrome, Adrenal insufficiency, Hyperthyroidism, Hypothyroidism, postorgasmic illness syndrome (POIS).[1][2][3]


Chronic fatigue syndrome aka Myalgic Encephalomyelitis, Channelopathy, Ehlers Danlos Syndrome, Stickler Syndrome, Hypokalemia, Hypotonia (Low Muscle Tone), Exercise intolerance, Mastocytosis, Peripheral neuropathy, Eosinophilia myalgia syndrome, Fibromyalgia, Barcoo Fever, Herpes, Hemochromatosis aka Iron Overload Disorder, Delayed onset muscle soreness, AIDS, HIV, Tumor-induced osteomalacia, Hypovitaminosis D[5]

Withdrawal syndrome from certain drugs[edit]

Sudden cessation of high-dose corticosteroids, opioids, barbiturates, benzodiazepines, caffeine or alcohol can induce myalgia in many respects.

See also[edit]


  1. ^ a b Balon R, Segraves RT, ed. (2005). Handbook of Sexual Dysfunction. Taylor & Francis. ISBN 9780824758264. 
  2. ^ a b Wylie KR, ed. (2015). ABC of Sexual Health. John Wiley & Sons. p. 75. ISBN 9781118665565. 
  3. ^ a b "Postorgasmic illness syndrome". Genetic and Rare Diseases Information Center (GARD). National Institutes of Health. 2015. Retrieved 30 July 2015. 
  4. ^ a b MedlinePlus
  5. ^ Glueck, Charles (August 30, 2013). North American Journal of Medical Sciences 5 (8): 494-495. doi:10.4103/1947-2714.117325;year=2013;volume=5;issue=8;spage=494;epage=495;aulast=Glueck.  Missing or empty |title= (help)

External links[edit]