Mycobacterial porin

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1uun opm.png
Symbol MspA
Pfam PF09203
InterPro IPR015286
SCOP 1uun
TCDB 1.B.24
OPM superfamily 305
OPM protein 1uun

MspA porin is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each protein subunit contains a beta-sandwich of immunnoglobulin-like topology and a beta-ribbon arm that forms an oligomeric transmembrane beta-barrel.[1]


  1. ^ Schulz GE, Faller M, Niederweis M (2004). "The structure of a mycobacterial outer-membrane channel". Science. 303 (5661): 1189–92. PMID 14976314. doi:10.1126/science.1094114.