Mycobacterium avium complex
||It has been suggested that this article be merged into Mycobacterium avium-intracellulare infection. (Discuss) Proposed since December 2015.|
Mycobacterium avium complex (MAC), also called Mycobacterium avium-intracellulare complex, is a microbial complex of 2 Mycobacterium species, Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium chimaera. It causes Mycobacterium avium-intracellulare infection.
The Mycobacterium avium complex (MAC) includes ubiquitous atypical bacteria, i.e. nontuberculous mycobacteria or NTM, found in the environment which can infect patients with HIV and low CD4 cell count (below 100/microliter); mode of infection is usually inhalation or ingestion.
MAC causes disseminated disease in up to 40% of patients with human immunodeficiency virus (HIV) in the United States, producing fever, sweats, weight loss, and anemia. Disseminated MAC characteristically affects patients with advanced HIV disease and peripheral CD4+ T-lymphocyte counts less than 100 cells/uL. Effective prevention and therapy of MAC has the potential to contribute substantially to improved quality of life and duration of survival for HIV-infected persons.
This article incorporates public domain material from the Centers for Disease Control and Prevention document "Recommendations on Prophylaxis and Therapy for Disseminated Mycobacterium avium Complex for Adults and Adolescents Infected with Human Immunodeficiency Virus".
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