Mycobacterium lepromatosis is a bacterium that, along with Mycobacterium leprae, causes leprosy (Hansen's disease). It was only recently discovered, in 2008. Analysis of its 16S rRNA gene confirms that the species is distinct from Mycobacterium leprae.
M. lepromatosis is an acid-fast bacillus (AFB) which causes diffuse lepromatous leprosy (DLL). DLL is mainly found in Mexico and the Caribbean. DLL is a severe form of leprosy which manifests through nerve invasion and extensive skin ulcerations due to massive AFB burden in internal organs. M. lepromatosis, like M. leprae, has not been cultured in the laboratory because they both lack genes necessary to grow outside of their hosts. These genes are believed by scientists to have been lost through reductive evolution.
- Nair, R. Geetha; Li, Wei; Spencer, John S.; May, Gregory S.; Schoberle, Taylor; Sizer, Kurt C.; Seo, Yiel-Hea; Han, Xiang Y. (2008). "A New Mycobacterium Species Causing Diffuse Lepromatous Leprosy". American Journal of Clinical Pathology 130 (6): 856–64. doi:10.1309/AJCPP72FJZZRRVMM. PMID 19019760. Lay summary.
- Han, Xiang Y.; Sizer, Kurt C.; Thompson, Erika J.; Kabanja, Juma; Li, Jun; Hu, Peter; Gómez-Valero, Laura; Silva, Francisco J. (2009). "Comparative Sequence Analysis of Mycobacterium leprae and the New Leprosy-Causing Mycobacterium lepromatosis". Journal of Bacteriology 191 (19): 6067–74. doi:10.1128/JB.00762-09. PMC 2747882. PMID 19633074.
- Dermatologic Manifestations of Leprosy at eMedicine