This article needs attention from an expert in medicine. Please add a reason or a talk parameter to this template to explain the issue with the article. WikiProject Medicine (or its Portal) may be able to help recruit an expert.(February 2009)
The common myeloid progenitor can differentiate in the bone marrow into red blood cells and megakaryocytes (leading to platelets) as well as mast cells and myeloblasts, the latter leading to the myelocytic line (granulocytes) and to monocytes, macrophages, and dendritic cells of the innate immune system. The granulocytes, also called polymorphonuclear leukocytes because of their multilobed nuclei, are three short lived cell types including eosinophils, basophils, and neutrophils. A granulocyte differentiates into a distinct cell type by a process called granulopoiesis. In this process it first transforms from a common myeloblast (myeloid progenitor) to a common promyelocyte. This promyelocyte gives rise to a unique myelocyte that for the first time can be classified as an eosinophil, basophil, or neutrophil progenitor based on the histological staining affinity (eosinophilic, basophilic, or neutral granules). The unique myelocyte next differentiates into a metamyelocyte and then a band cell, with a "C" shaped nucleus, before becoming a mature eosinophil, basophil, or neutrophil. Macrophages come from monoblast progenitors that differentriate into promonocytes, which mature into monocytes. Monocytes eventually enter the tissues and become macrophages.