|Urine from a person with rhabdomyolysis showing the characteristic brown discoloration as a result of myoglobinuria|
|Classification and external resources|
Signs and symptoms
Signs and symptoms of myoglobinuria are usually nonspecific and needs some clinical prudence.Therefore, among the possible signs and symptoms to look for would be:
- Swollen and painful muscles
- Fever, nausea
- Delirium (elderly individuals)
- Dark urine
- Calcium ions (decrease)
Trauma, vascular problems, malignant hyperthermia, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys. Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of renal problems, it can occlude the renal filtration system leading to acute tubular necrosis and acute renal insufficiency.
Other causes of myoglobinuria include:
- McArdle's disease
- Phosphofructokinase deficiency
- Carnitine palmitoyltransferase II deficiency
- Malignant hyperthermia
- Lactate dehydrogenase deficiency
- Thermal or electrical burn
Myoglobinuria pathophysiology consist of a series of metabolic actions in which damage to muscle cells affect calcium mechanisms, thereby increasing free ionized calcium (cytoplasm). This in turn affects several enzymes that are calcium dependent, thereby compromising the cell membrane, which in turn causes the release of myoglobin.
After centrifuging, the urine of myoglobinuria is red, where the urine of hemoglobinuria after centrifuge is pink to clear.
Hospitalization and IV hydration should be the first step in any patient suspected of having myoglobinuria or rhabdomyolysis. The goal is to induce a brisk diuresis to prevent myoglobin precipitation and deposition, which can cause acute kidney injury. Mannitol can be added to assist with diuresis. Adding sodium bicarbonate to the IV fluids will cause alkalinzation of the urine, believed to reduce the breakdown of myoglobin into its nephrotoxic metabolites, thus preventing renal damage. Often, IV normal saline is all that is needed to induce diuresis and alkalinize the urine.
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- "Rhabdomyolysis and Other Causes of Myoglobinuria". Patient. EMIS Group. Retrieved 10 September 2015.
- Toscano A, Musumeci O (October 2007). "Tarui disease and distal glycogenoses: clinical and genetic update". Acta Myol. 26 (2): 105–7. PMC 2949577. PMID 18421897.
- "Myoglobinuria". eMedicine. Medscare. Retrieved 10 September 2015.
- Pedley, edited by Lewis P. Rowland, Timothy A. (2010). Merritt's neurology (12th ed.). Philadelphia, PA: Lippincott Williams & Wilkins. p. 885. ISBN 978-0781791861. Retrieved 10 September 2015.
- Nyhan, edited by Georg F. Hoffmann, Johannes Zschocke, William L. (2010). Inherited metabolic diseases : a clinical approach. Heidelberg: Springer. p. 165. ISBN 978-3-540-74722-2. Retrieved 10 September 2015.
- Overview on the Neuromuscular disease center website.