Myristoyl-CoA 11-(E) desaturase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
myristoyl-CoA 11-(E) desaturase
Identifiers
EC number 1.14.99.31
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a myristoyl-CoA 11-(E) desaturase (EC 1.14.99.31) is an enzyme that catalyzes the chemical reaction

myristoyl-CoA + NAD(P)H + H+ + O2 (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O

The 5 substrates of this enzyme are myristoyl-CoA, NADH, NADPH, H+, and O2, whereas its 4 products are (E)-11-tetradecenoyl-CoA, NAD+, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating].

References[edit]

  • Navaro I, Font I, Fabrias G, Camps F (1997). "Stereospecificity of the (E)- and (Z)-11 myristoyl desaturases in the biosynthesis of Spodoptera littoralis sex pheromone". J. Am. Chem. Soc. 119 (46): 11335–11336. doi:10.1021/ja972577v.