Myxedema coma

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Myxedema coma
SpecialtyEndocrinology Edit this on Wikidata

Myxedema coma is a state of decompensated hypothyroidism. A person may have laboratory values identical to a "normal" hypothyroid state, but a stressful event (such as an infection, myocardial infarction, or stroke) precipitates the myxedema coma state, usually in the elderly. Primary symptoms of myxedema coma are altered mental status and low body temperature. Low blood sugar, low blood pressure, hyponatremia, hypercapnia, hypoxia, slowed heart rate, and hypoventilation may also occur.[1] Myxedema, although included in the name, is not necessarily seen in myxedema coma.[citation needed] Coma is also not necessarily seen in myxedema coma.[2]

According to newer theories, myxedema coma could result from allostatic overload in a situation where the effects of hypothyroidism are amplified by nonthyroidal illness syndrome.[3]

See also[edit]


  1. ^ Berghe, edited by Greet van den; Wartofsky, Leonard (2008). Acute endocrinology : from cause to consequence (1 ed.). New York: Humana Press. pp. 29–44. ISBN 978-1-60327-176-9.CS1 maint: extra text: authors list (link)
  2. ^ Gardner, David G., Shoback, Dolores M., Greenspan, Francis S. (2017). Greenspan's basic & clinical endocrinology (10th ed.). McGraw-Hill Education. p. 783. ISBN 978-1259589294. OCLC 1075522289.CS1 maint: multiple names: authors list (link)
  3. ^ Chatzitomaris, Apostolos; Hoermann, Rudolf; Midgley, John E.; Hering, Steffen; Urban, Aline; Dietrich, Barbara; Abood, Assjana; Klein, Harald H.; Dietrich, Johannes W. (20 July 2017). "Thyroid Allostasis–Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming". Frontiers in Endocrinology. 8: 163. doi:10.3389/fendo.2017.00163. PMC 5517413. PMID 28775711.

External links[edit]

External resources