N,N'-diacetyllegionaminate synthase
| N,N'-diacetyllegionaminate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.101 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
N,N'-diacetyllegionaminate synthase (EC 2.5.1.101, neuB (gene), legI (gene)) is an enzyme with systematic name phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase.[1][2] This enzyme catalyses the following chemical reaction
- 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O N,N'-diacetyllegionaminate + phosphate
This enzyme requires a divalent metal such as Mn2+.
References[edit]
- ^ Glaze PA, Watson DC, Young NM, Tanner ME (March 2008). "Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila". Biochemistry. 47 (10): 3272–82. doi:10.1021/bi702364s. PMID 18275154.
- ^ Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM (July 2009). "The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors". Glycobiology. 19 (7): 715–25. doi:10.1093/glycob/cwp039. PMID 19282391.
External links[edit]
- N,N'-diacetyllegionaminate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
