N-Methyl-PPPA

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
N-Methyl-PPPA
N-Methyl-PPPA.svg
Clinical data
SynonymsDetrifluoromethylfluoxetine
ATC code
  • None
Identifiers
ChemSpider
Chemical and physical data
FormulaC16H19NO
Molar mass241.328 g/mol g·mol−1
3D model (JSmol)

N-Methyl-PPPA, or N-methyl-3-phenoxy-3-phenylpropan-1-amine, is a serotonin-norepinephrine reuptake inhibitor (SNRI) which was developed by Eli Lilly from diphenhydramine in the early 1970s while in search of new antidepressants, but was never marketed.[1][2][3] It is closely related structurally to fluoxetine, atomoxetine, and nisoxetine.[1][2][3]

See also[edit]

References[edit]

  1. ^ a b Francisco Lopez-Munoz; Cecilio Alamo (9 September 2011). Neurobiology of Depression. CRC Press. pp. 132–. ISBN 978-1-4398-3850-1.
  2. ^ a b Walter Sneader (31 October 2005). Drug Discovery: A History. John Wiley & Sons. pp. 416–417. ISBN 978-0-470-01552-0.
  3. ^ a b Wong DT, Bymaster FP, Engleman EA (1995). "Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication". Life Sci. 57 (5): 411–41. doi:10.1016/0024-3205(95)00209-o. PMID 7623609.