N-Oxalylglycine

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N-Oxalylglycine
Partially condensed, skeletal formula of N-oxalylglycine
Names
IUPAC name
2-(Carboxymethylamino)-2-oxoacetic acid
Other names
[(Carboxymethyl)amino](oxo)acetic acid
Identifiers
3D model (JSmol)
Abbreviations NOG
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.213.188
MeSH oxalylglycine
Properties
C4H5NO5
Molar mass 147.09 g·mol−1
Appearance Colorless solid
log P 1.232
Acidity (pKa) 2.827
Basicity (pKb) 11.170
Related compounds
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

N-Oxalylglycine is the organic compound with the formula HO2CC(O)NHCH2CO2H. This colourless solid is used as an inhibitor of α-ketoglutarate-dependent enzymes.[1] It is isosteric with α-ketoglutaric acid. Such enzymes are pervasive and, for example, are required for the synthesis of 4-hydroxyproline.

References[edit]

  1. ^ Hausinger, R. P."Fe(II)/α-ketoglutarate-dependent hydroxylases and related enzymes" Critical Reviews of Biochemical Molecular Biology 2004, 39: pp 21-68. doi:10.1080/10409230490440541