N-acetylglucosamine-6-phosphate deacetylase

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N-acetylglucosamine-6-phosphate deacetylase
Identifiers
EC number 3.5.1.25
CAS number 9027-50-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) is an enzyme that catalyzes the chemical reaction

N-acetyl-D-glucosamine 6-phosphate + H2O D-glucosamine 6-phosphate + acetate

Thus, the two substrates of this enzyme are N-acetyl-D-glucosamine 6-phosphate and H2O, whereas its two products are D-glucosamine 6-phosphate and acetate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-acetyl-D-glucosamine-6-phosphate amidohydrolase. Other names in common use include acetylglucosamine phosphate deacetylase, acetylaminodeoxyglucosephosphate acetylhydrolase, and 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase. This enzyme participates in aminosugars metabolism.

Structural studies[edit]

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1O12, 1UN7, 1YMY, 1YRR, 2P50, and 2P53.

References[edit]