N-Acetylglutamic acid

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N-Acetylglutamic acid
Skeletal formula of N-acetylglutamic acid
IUPAC name
2-Acetamidopentanedioic acid[1]
Other names
Acetylglutamic acid[citation needed]
5817-08-3 N
19146-55-5 R N
1188-37-0 S N
3DMet B00147
1727473 S
ChemSpider 180 YesY
1272049 R N
64077 S N
DrugBank DB04075 N
EC Number 227-388-6
Jmol interactive 3D Image
KEGG C00624 N
MeSH N-acetylglutamate
PubChem 185
1560015 R
70914 S
RTECS number LZ9725000 S
Molar mass 189.17 g·mol−1
Appearance White crystals
Density 1 g mL−1
Melting point 191 to 194 °C (376 to 381 °F; 464 to 467 K)
36 g L−1
Lethal dose or concentration (LD, LC):
>7 g kg−1 (oral, rat)
Related compounds
Related alkanoic acids
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

N-Acetylglutamic acid (abbreviated NAcGlu) is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetylglutamate synthase. Arginine is the activator for this reaction.

The reverse reaction, hydrolysis of the acetyl group, is catalyzed by a specific hydrolase.

NAcGlu activates carbamoyl phosphate synthetase in the urea cycle.

See also[edit]


  1. ^ "N-Acetyl-DL-glutamic acid - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Retrieved 25 June 2012. 

External links[edit]