N-acetylneuraminylgalactosylglucosylceramide b-1,4-N-acetylgalactosaminyltransferase

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N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase
Identifiers
EC number 2.4.1.165
CAS number 109136-50-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.165, uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase, UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-N-acetylgalactosaminyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-galactosamine + N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

This enzyme requires Mn2+.

References[edit]

  1. ^ Chien, J.-L.; Williams, T.; Basu, S. (1973). "Biosynthesis of a globoside-type glycosphingolipid by a β-N-acetylgalactosaminyltransferase from embryonic chicken brain". J. Biol. Chem. 248 (5): 1778–1785. PMID 4632917. 
  2. ^ Piller, F.; Blanchard, D.; Huet, M.; Cartron, J.-P. (1986). "Identification of a α-NeuAc-(2-3)-β-D-galactopyranosyl N-acetyl-β-D-galactosaminyltransferase in human kidney". Carbohydr. Res. 149: 171–184. doi:10.1016/S0008-6215(00)90376-8. PMID 2425965. 
  3. ^ Takeya, A.; Hosomi, O.; Kogure, T. (1987). "Identification and characterization of UDP-GalNAc: NeuAc α2-3Gal β1-4Glc(NAc) β1-4(GalNAc to Gal)N-acetylgalactosaminyltransferase in human blood plasma". J. Biochem. 101 (1): 251–259. PMID 3106337. 

External links[edit]