N-acylglucosamine-6-phosphate 2-epimerase

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N-acylglucosamine-6-phosphate 2-epimerase
EC no.
CAS no.37318-35-7
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a N-acylglucosamine-6-phosphate 2-epimerase (EC is an enzyme that catalyzes the chemical reaction

N-acyl-D-glucosamine 6-phosphate N-acyl-D-mannosamine 6-phosphate

Hence, this enzyme has one substrate, N-acyl-D-glucosamine 6-phosphate, and one product, N-acyl-D-mannosamine 6-phosphate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine-6-phosphate 2-epimerase. Other names in common use include acylglucosamine-6-phosphate 2-epimerase, and acylglucosamine phosphate 2-epimerase. This enzyme participates in aminosugars metabolism.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y0E and 1YXY.


  • Ghosh S, Roseman S (April 1965). "The Sialic Acids. Iv. N-Acyl--D-Glucosamine 6-Phosphate 2-Epimerase". The Journal of Biological Chemistry. 240: 1525–30. doi:10.1016/S0021-9258(18)97467-3. PMID 14285487.