N-acylglucosamine-6-phosphate 2-epimerase

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N-acylglucosamine-6-phosphate 2-epimerase
Identifiers
EC number5.1.3.9
CAS number37318-35-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a N-acylglucosamine-6-phosphate 2-epimerase (EC 5.1.3.9) is an enzyme that catalyzes the chemical reaction

N-acyl-D-glucosamine 6-phosphate N-acyl-D-mannosamine 6-phosphate

Hence, this enzyme has one substrate, N-acyl-D-glucosamine 6-phosphate, and one product, N-acyl-D-mannosamine 6-phosphate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine-6-phosphate 2-epimerase. Other names in common use include acylglucosamine-6-phosphate 2-epimerase, and acylglucosamine phosphate 2-epimerase. This enzyme participates in aminosugars metabolism.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y0E and 1YXY.

References[edit]

  • Ghosh S, Roseman S (April 1965). "THE SIALIC ACIDS. IV. N-ACYL--D-GLUCOSAMINE 6-PHOSPHATE 2-EPIMERASE". The Journal of Biological Chemistry. 240: 1525–30. PMID 14285487.