In enzymology, a N-acylglucosamine-6-phosphate 2-epimerase (EC 220.127.116.11) is an enzyme that catalyzes the chemical reaction
- N-acyl-D-glucosamine 6-phosphate N-acyl-D-mannosamine 6-phosphate
Hence, this enzyme has one substrate, N-acyl-D-glucosamine 6-phosphate, and one product, N-acyl-D-mannosamine 6-phosphate.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine-6-phosphate 2-epimerase. Other names in common use include acylglucosamine-6-phosphate 2-epimerase, and acylglucosamine phosphate 2-epimerase. This enzyme participates in aminosugars metabolism.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y0E and 1YXY.
- Ghosh S, Roseman S (April 1965). "THE SIALIC ACIDS. IV. N-ACYL--D-GLUCOSAMINE 6-PHOSPHATE 2-EPIMERASE". The Journal of Biological Chemistry. 240: 1525–30. PMID 14285487.