N-carbamoylsarcosine amidase

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N-carbamoylsarcosine amidase
EC no.
CAS no.92767-52-7
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a N-carbamoylsarcosine amidase (EC is an enzyme that catalyzes the chemical reaction

N-carbamoylsarcosine + H2O sarcosine + CO2 + NH3

Thus, the two substrates of this enzyme are N-carbamoylsarcosine and H2O, whereas its 3 products are sarcosine, CO2, and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-carbamoylsarcosine amidohydrolase. This enzyme is also called carbamoylsarcosine amidase. This enzyme participates in arginine and proline metabolism.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1NBA.


  • Deeg R, Roeder A, Siedel J, Gauhl H, Ziegenhorn J (1984). "Process and reagent for the determination of N-carbamoylsarcosine with the use of a new enzyme". Chem. Abstr. 101: 18751.